Hypersensitivity to ketorolac or other components of the drug and to other NSAIDs.

- Active peptic ulcer, recent gastrointestinal bleeding or perforation, ulcer decease or gastrointestinal bleeding in anamnesis;

The presence or suspected gastrointestinal bleeding or cerebral hemorrhage. The state with the high risk of bleeding or incomplete hemostasis, hemorrhagic diathesis.

- severe renal insufficiency (blood serum creatinine more than 160 mmol/L);

The risk of renal failure due to reduction of the volume of liquid.

blood-clotting disorders

The simultaneous use of antiplatelet drugs (acetylsalicylic acid), anticoagulants, including warfarin and low-dose heparin (2,500-5,000 units every 12 hours).

Severe cardiac and hepatic failure.

Contraindicated in patients in whom other prostaglandin synthesis inhibitors induce allergic reactions such asthma, rhinitis, angioedema or urticaria.

Bronchial asthma, bronchospasm, polyps in nasal cavity, angioedema in anamnesis.

The drug is contraindicated during labor pains.

-Simultaneous treatment with other nonsteroidal anti-inflammatory drugs (NSAIDs) (including selective inhibitors of cyclooxygenase), acetylsalicylic acid, warfarin, pentoxifylin, probenecid or lithium salts;.

Hypersensitivity to acetylsalicylic acid or other inhibitors of prostaglandin synthesis (such patients have severe anaphylactic reactions).

- Do not use as analgesic before and during surgery;

Epidural or intrathecal administration of the drug are contraindicated.