Therapy resistant schizophrenia

Azaleptol should be administered only in those patients with schizophrenia who are resistant to therapy or tolerate to standard neuroleptics accordance with the following definitions.

Resistance to standard neuroleptics - is a condition where previous treatment with conventional antipsychotic drugs at the appropriate dosage did not lead to adequate clinical improvement for a sufficient period of time

The intolerance to standard neuroleptics - is a condition where there are heavy unmanageable side effects of neurological character  (extrapyramidal symptoms and tardive dyskinesia) that inhibit effective neuroleptic therapy with standard neuroleptics .

The risk of recurrent suicidal attempts

Azaleptol shown to reduce long-term risk of recurrence of suicidal behavior in patients with schizophrenia or schizoaffective disorder who are assessed with respect to this risk based on their medical history and current clinical picture.

Psychotic disorders during therapy of Parkinson's Disease

Azaleptol is indicated for the treatment of psychotic disorders, developing during Parkinson's disease, if standard therapy is proved ineffective.

The ineffectiveness of standard therapy is defined as the lack of control over the psychotic symptoms and / or the emergence of functionally unacceptable increased severity of motor symptoms after taking the following measures:

• cancellation of anticholinergic drugs, including tricyclic antidepressants;
• an attempt to reduce the dose of dopaminergic antiparkinsonian drugs.