Increased hypersensitivity to any component of the drug.

Epilepsy and other diseases, which are accompanied by a tendency to seizures, severe psychosis, polio (including history), toxic hepatitis in anamnesis due to the use of derivatives of isonicotinic acid hydrazide (ftivazid etc), Expressed atherosclerosis, acute liver and / or renal failure; renal failure (nephritis), liver (hepatitis, cirrhosis), liver disease in the acute stage; amyloidosis, peptic ulcer disease, myxedema, cardiac decompensation, hypothyroidism.