Hypersensitivity to any components of the drug, nephrolithiasis, severe renal dysfunction, chronic glomerulonephritis, gout, hyperuricemia, erythremia, polycythemia, propensity to thrombosis, thrombophlebitis, embolism, hyperthyroidism, chronic heart failure, sarcoidosis in anamnesis, active peptic ulcer and duodenal intestine (in connection with a possible increase in the acidity of gastric juice), liver function abnormality, active hepatitis, neoplasms (unless accompanied by megaloblastic anemia), arterial hypertension (severe), hypervitaminosis of A and E, metabolic disorders of iron and copper, hypercalcemia , fructose intolerance, glucose-galactose malabsorption syndrome.